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Direct renin inhibitors block the enzyme renin from triggering a process that helps regulate blood pressure. As a result, blood vessels relax and widen, making it easier for blood to flow through the vessels, which lowers blood pressure.
Direct renin inhibitors, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin II receptor blockers (ARBs) all target the same process that narrows blood vessels. But each type of medicine blocks a different part of the process.
Direct renin inhibitors are used to lower high blood pressure.footnote 1
Direct renin inhibitors can lower blood pressure.footnote 2
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call 911 or other emergency services right away if you have:
Call your doctor if you have:
Common side effects of this medicine include:
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
Direct renin inhibitors are a newer type of medicine for high blood pressure. So doctors don't know about safety after a long time or how well they work after a long time.
Before you take a direct renin inhibitor, tell your doctor about any other medicines you take and any other health problems you have.
For tips on taking blood pressure medicine, see:
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Do not use this medicine if you are pregnant, breastfeeding, or planning to get pregnant. If you need to use this medicine, talk to your doctor about how you can prevent pregnancy.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
CitationsDrugs for hypertension (2012). Treatment Guidelines From The Medical Letter, 10(113): 1-10.Aliskiren/valsartan (Valturna) for hypertension (2009). Medical Letter On Drugs and Therapeutics, 51(1326): 94-95.
ByHealthwise StaffPrimary Medical ReviewerE. Gregory Thompson, MD - Internal MedicineMartin J. Gabica, MD - Family MedicineSpecialist Medical ReviewerRobert A. Kloner, MD, PhD - Cardiology
Current as ofOctober 5, 2017
Current as of: October 5, 2017
Author: Healthwise Staff
Medical Review: E. Gregory Thompson, MD - Internal Medicine & Martin J. Gabica, MD - Family Medicine & Robert A. Kloner, MD, PhD - Cardiology
To learn more about Healthwise, visit Healthwise.org.
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