Naloxone (Overdose Prevention)

Find Naloxone in your area
Anyone can request naloxone from a local pharmacy without a prescription. Prescriptions are 100% covered for Medicaid clients; co-pays may exist for those with private insurance.

Recognize overdose signs

  • Person won’t wake up even if you shake them or rub their breast bone
  • Breathing is slow, shallow or even stops. Gurgling or snoring noises
  • Lips and fingernails turn blue or gray
  • An exhaled breath with a very distinct, labored sound coming from the throat (death rattle) is a telltale sign a person is in a critical emergency medical state

Recognize overmedication signs, which may progress to overdose:

  • Unusual sleepiness or drowsiness
  • Mental confusion, slurred speech, intoxicated behavior
  • Slow or shallow breathing
  • Pinpoint pupils
  • Slow heartbeat
  • Difficulty waking the person from sleep

What is naloxone?

  • Naloxone is a medication designed to rapidly reverse opioid overdose.
  • Naloxone is a “rescue drug” that has been approved by the FDA and can be administered in a number of ways that make it possible for a lay person to use.

How does naloxone work?

  • Naloxone is an opioid receptor antagonist medication that can reverse an opioid overdose. Opioid antagonists bind to opioid receptors to block and reverse the effects of opioids.
  • Naloxone is administered when a patient is showing signs of an opioid overdose. It works by rapidly binding to opioid receptors, preventing opioids (e.g., heroin) from activating them.
  • It can quickly restore normal respiration to a person whose breathing has slowed or stopped as a result of overdosing with heroin or prescription opioid pain medications.
  • Opioid overdose-related deaths can be prevented when naloxone is administered in a timely manner.

How is naloxone administered?

  • Naloxone can be administered intramuscularly (into the muscle), intravenously (into the vein), subcutaneously (under the skin), and as a nasal spray.
  • FDA-approved formulations of naloxone include:
    • Injectable Naloxone HCl solution- (professional training required)
  • NARCAN®- a prepacked nasal spray that is sprayed into one nostril while patients lay on their back
  • EVZIO®- an auto-injection device that can inject naloxone into a patient’s outer thigh.
  • Find Naloxone in your area

How can I get naloxone?

  • Ask your pharmacist how to obtain and use naloxone. If you are a Medicaid client, they will pay in full. If you have health insurance, you will be responsible for the copay.
  • Ask your doctor for a prescription or if they have a kit you can use.
  • Your county Public Health Office(Be sure to check if they carry naloxone and hours of operation.)
  • Southwest CARE Center Pharmacy in Santa Fe
  • Santa Fe Mountain Center in Espanola or Pojoaque
  • Harm reduction programs
  • Substance abuse treatment and long-term care facilities
  • If you live in Bernalillo, Santa Fe, Rio Arriba or Doña Ana counties, you can also contact a Prescription Drug Overdose (PDO) County Coordinators:
    • Bernalillo County: English: (505) 246-1638 & Spanish (505) 328-1391
    • Santa Fe and Rio Arriba Counties: English (505) 270-5943 & Spanish (505) 670-4220
    • Doña Ana County: (575) 525-5870 for English & Spanish
  • Naloxone is a prescription drug. Regulations for dispensing naloxone vary from state to state. Some states allow for standing orders written by physicians allowing the patient to receive naloxone without a traditional written prescription. New Mexico allows pharmacists to dispense naloxone to patients without physician involvement. This should be updated to focus on NM rules.
  • Physicians can prescribe naloxone to patients who are in medication-assisted treatment (MAT).
  • Patients given an automatic injection device or nasal spray should keep the item available at all times. Medication should be replaced when the expiration date passes.
  • Find Naloxone in your area

Who can administer naloxone?

  • Naloxone is a regulated medication and must be administered properly.
  • A doctor or pharmacist can show patients, their family members, or caregivers how to administer naloxone. Intravenous injection every two to three minutes is recommended in emergencies.
  • New Mexico requires all local and state law enforcement agencies to provide officers with antidote naloxone to curb deaths from opioid and heroin overdoses.

Can naloxone be misused?

  • Naloxone does not have the potential for abuse. It reverses the effects of opioid overdose.

Can pregnant women be given naloxone?

  • Pregnant women can be safely given naloxone in limited doses under the supervision of a doctor.

Where can I learn more about naloxone?

VIDEOS: How to prevent, recognize and respond to an overdose and how to get Naloxone.

Recovery Testimonial - A Conversation with John Herrera

SAMHSA Opioid Overdose Prevention Toolkits

  • The Substance Abuse and Mental Health Services Administration (SAMHSA) has published an opioid overdose prevention guide, SAMHSA Opioid Overdose Prevention Toolkit.
  • English version
    Spanish version

Don’t leave a friend to sleep it off. NM’s Good Samaritan law protects you even if you shared drugs or possess paraphernalia. The protections may not extend to people with outstanding warrants, people on probation or parole, or if there is evidence of criminal activity at the scene.

Additional information on Naloxone can be accessed through these links: